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Homeovitality® products

Homeovitality Endocare

May support vascular integrity & functionality

Homeovitality® Endocare

Endocare has been developed to suppress endothelial cell mediated chronic inflammation by targeting the SIRT6 gene.

What does SIRT6 do?

Chronic inflammation predisposes to development of many serious diseases.

There are a number of ways in which inflammation can be mediated. It can be brought about by excessive immune responsiveness. This type of inflammation can be controlled by promoting the production of the immune suppressant, IL-10. This forms the basis of the Allergicare Micro-DNA therapy preparation.

Chronic inflammation may also be driven by dysfunctional epithelial cells.

Endothelial cells (the endothelium) line the inner surface of the vessels of the blood system, including arteries, veins and capillaries and the lymphatic system. The endothelium plays a very important role on controlling optimum passage of many substances such as hormones and immune cells into surrounding tissues, as needed. When the function of endothelial cells is impaired, they release a range of pro-inflammatory substances that cause great damage to themselves and surrounding tissues. The result of endothelial damage leads to development of many disorders associated with local and systemic inflammation such as heart disease, atherosclerosis, diabetes, rheumatoid arthritis, abnormal growth of blood vessels (angiogenesis), cancer and rapid ageing [1, 2 & 3].

The release of inflammatory mediators from dysfunctional endothelial cells has been shown to be controlled by the recently discovered histone deacetylase SIRT6. Studies have shown that decreased expression of SIRT6 in endothelial cells leads to serious chronic inflammation. Inflammation resulting from dysfunctional endothelial cells is reduced when SIRT6 activity is increased, for review see Ref. 4.


  1. Cai. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circulation Research. (2000); 87, 840.
  2. Szekanecz. Mechanisms of disease: angiogenesis in inflammatory diseases. Nature Clinical Practice Rheumatology. (2007); 3,635.
  3. Sprague. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochemical Pharmacology. (2009); 78, 539.
  4. Lappas. Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells. Mediators Inflamm. doi: 10.1155/2012/597514.

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Additional Information




Acidum Nucleicum ST6 UHD at 10-12, Stabiliser (Sodium Phosphate buffer) - 0.014mg/mL, Ethanol (25%) in purified water

Volume (of 1 bottle)

Each bottle contains 50mL of liquid which lasts 1½ months (if used twice a day)

Directions for use

Shake before use. Twice daily, add 8 drops to a little clean water. On a clean palate, rinse round mouth and swallow. More than one product can be taken in the same glass.

Do not use if seal is broken. Keep product in original container.


Keep away from strong odours. Store at room temperature, out of direct sunlight, excessive heat and away from children. Keep product in original container.


It is recommended that you inform your medical doctor/GP that you are taking Homeovitality products. Homeovitality products should not be used as a substitute for treatments prescribed by your physician (read the full disclaimer). A practitioner's prescription is not required to use Homeovitality products.

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